Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.

ABSTRACT:

Background

Genome-wide association studies have detected a large number of single-nucleotide polymorphisms (SNPs) associated with complex traits in diverse ancestral groups. However, the trans-ethnic similarity and diversity of genetic architecture is not well understood currently.

Results

By leveraging summary statistics of 37 traits from East Asian (N_max=254,373) or European (N_max=693,529) populations, we first evaluated the trans-ethnic genetic correlation (ρ_g) and found substantial evidence of shared genetic overlap underlying these traits between the two populations, with [Formula: see text] ranging from 0.53 (se = 0.11) for adult-onset asthma to 0.98 (se = 0.17) for hemoglobin A1c. However, 88.9% of the genetic correlation estimates wer

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10258967 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature