YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice.

ABSTRACT:

Background and aims

Peroxisome proliferator-activated receptor α (PPARα, NR1C1) is a ligand-activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly and plays an important role in liver regeneration, but the underlying mechanisms remain unclear.

Approach and results

In this study, the effect of PPARα activation on liver enlargement and regeneration was investigated in several strains of genetically modified mice. PPARα activation by the specific agonist WY-14643 significantly induced hepatomegaly and accelerated liver regeneration after 70% partial hepatectomy (PHx) in wild-type mice and Ppara^fl/fl mice, while these effects were abolished in hepatocyte-specific Ppara-deficient (Ppara

SUBMITTER: Fan S 

PROVIDER: S-EPMC10259205 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature