Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition.

ABSTRACT: The tumor stroma of most solid malignancies is characterized by a pathological accumulation of pro-angiogenic and pro-tumorigenic hyaluronan driving tumorigenesis and metastatic potential. Of all three hyaluronan synthase isoforms, HAS2 is the primary enzyme that promotes the build-up of tumorigenic HA in breast cancer. Previously, we discovered that endorepellin, the angiostatic C-terminal fragment of perlecan, evokes a catabolic mechanism targeting endothelial HAS2 and hyaluronan via autophagic induction. To explore the translational implications of endorepellin in breast cancer, we created a double transgenic, inducible Tie2Cre^ERT2;endorepellin(ER)^Ki mouse line that expresses recombinant endorepellin specifically from the endothelium. We investigated the therapeuti

SUBMITTER: Chen CG 

PROVIDER: S-EPMC10259220 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature