Tumour volume is a predictor of lymphovascular invasion in differentiated small thyroid cancer.

ABSTRACT:

Objectives

For small thyroid cancers (≤2 cm), tumour volume may better predict aggressive disease, defined by lymphovascular invasion (LVI) than a traditional single measurement of diameter. We aimed to investigate the relationship between tumour diameter, volume and associated LVI.

Methods

Differentiated thyroid cancers (DTC) ≤ 2 cm surgically resected between 2007 and 2016 were analysed. Volume was calculated using the formula for an ellipsoid shape from pathological dimensions. A 'larger volume' cut-off was established by receiver operating characteristic (ROC) analysis using the presence of lateral cervical lymph node metastasis (N1b). Logistic regression was performed to compare the 'larger volume' cut-off to traditional measurements of diameter in the prediction.

Re

SUBMITTER: Vikneson K 

PROVIDER: S-EPMC10259346 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature