Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart.

ABSTRACT: Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with age and accelerate age-associated diseases. Senescent cells interfere with cardiac function and outcome post-MI with age, but studies have not been performed in larger animals, and the mechanisms are unknown. Specifically, age-associated changes in timecourse of senescence and related changes in inflammation and fibrosis are not well understood. Additionally, the cellular and systemic role of senescence and its inflammatory milieu in influencing arrhythmogenesis with age is not clear, particularly in large animal models with cardiac electrophysiology more

SUBMITTER: Baggett BC 

PROVIDER: S-EPMC10259375 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature