Association of PRDM16 rs12409277 and CtBP2 rs1561589 gene polymorphisms with lipid profile of adolescents.

ABSTRACT:

Introduction

Positive regulatory domain containing 16 (PRDM16) protein represents the key regulator of brown adipose tissue (BAT) development. It induces brown fat phenotype and represses white adipose tissue specific genes through the association with C-terminal binding co-repressor proteins (CtBP1 and CtBP2). In healthy adults presence of BAT has been associated with lower glucose, total cholesterol and low-density lipoprotein (LDL) cholesterol levels. Our aim was to analyze the association of PRDM16 gene (rs12409277) and CtBP2 gene (rs1561589) polymorphisms with body mass index (BMI), fasting glucose level and lipid profile of adolescents.

Material and methods

Our study included 295 healthy school children, 145 boys (49.2%) and 150 girls (50.8%), 15 y

SUBMITTER: Maksimovic N 

PROVIDER: S-EPMC10259392 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature