MRNA expression profiling of mitochondrial subunits in subjects with Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a common adult-onset neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in cell respiratory function and bioenergetics. Indeed, mitochondrial dysfunction causes insufficient energy production required to satisfy the needs of several organs, especially the nervous system. However, the profiling of messenger RNA (mRNA) expression of mitochondrial subunits in PD has not been systematically investigated yet.

Material and methods

We explored the mRNA expression of mitochondrial DNA (mtDNA) encoded respiratory chain (RC) subunits in 43 PD patients and 43 normal controls (NC). Next generation sequencing analy

SUBMITTER: Salemi M 

PROVIDER: S-EPMC10259399 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature