Mediation analysis of racial disparities in triple-negative breast cancer incidence among postmenopausal women.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is disproportionately higher in Black women relative to White women. The objective of this study was to examine to what extent the association between race/ethnicity and risk of TNBC is mediated by potentially modifiable factors.

Methods

A total of 128,623 Black and White women aged 50-79 years from the Women's Health Initiative were followed for a mean of 15.8 years. 643 incident TNBC cases (92 Black women and 551 White women) were confirmed by medical record review. Mediation analyses were conducted using an approach under a counterfactual framework.

Results

Black women had approximately twofold higher risk of TNBC compared with white women (HR = 1.93, 95% CI 1.52-2.45). We observed that 48% of the racial disparity was

SUBMITTER: Luo J 

PROVIDER: S-EPMC10259443 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature