Non-Contact Irreversible Electroporation in the Esophagus With a Wet Electrode Approach.

ABSTRACT: Our objective was to develop a technique for performing irreversible electroporation (IRE) of esophageal tumors while mitigating thermal damage to the healthy lumen wall. We investigated noncontact IRE using a wet electrode approach for tumor ablation in a human esophagus with finite element models for electric field distribution, joule heating, thermal flux, and metabolic heat generation. Simulation results indicated the feasibility of tumor ablation in the esophagus using an catheter mounted electrode immersed in diluted saline. The ablation size was clinically relevant, with substantially lesser thermal damage to the healthy esophageal wall when compared to IRE performed by placing a monopolar electrode directly into the tumor. Additional simulations were used to estimate ablation size

SUBMITTER: Sheehan MC 

PROVIDER: S-EPMC10259469 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature