Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization.

ABSTRACT: Sensory feedback is required for the stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems and physiological levels, yet relatively little is known about how disruptions to sensory input alter the molecular properties of associated motor systems. Songbird courtship song, a model for skilled behavior, is a learned and highly structured vocalization that is destabilized following deafening. Here, we sought to determine how the loss of auditory feedback modifies gene expression and its coordination across the birdsong sensorimotor circuit. To facilitate this system-wide analysis of transcriptional responses, we developed a gene expression profiling approa

SUBMITTER: Colquitt BM 

PROVIDER: S-EPMC10259477 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature