Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours.

ABSTRACT: Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating volume of activated tissue modeling, probabilistic mapping, normative connectomics, and atlas-derived transcriptomics. Ninety-one percent of the patients responded positively to treatment, with a more striking improvement recorded in the pediatric population. Probabilistic mapping revealed an optimized surgical target within the posterior-inferior-lateral region of the posterior hypothalamic area. Normative connectomic analyses identified fiber tracts and functionally connected with brain areas associated with sens

SUBMITTER: Gouveia FV 

PROVIDER: S-EPMC10259501 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature