Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin AT
PROVIDER: S-EPMC10259661 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Goodwin Amanda T AT John Alison E AE Joseph Chitra C Habgood Anthony A Tatler Amanda L AL Susztak Katalin K Palmer Matthew M Offermanns Stefan S Henderson Neil C NC Jenkins R Gisli RG
Development (Cambridge, England) 20230512 9
Alveolar development and repair require tight spatiotemporal regulation of numerous signalling pathways that are influenced by chemical and mechanical stimuli. Mesenchymal cells play key roles in numerous developmental processes. Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein α subunits Gαq and Gα11 (Gαq/11) transmit mechanical and chemical signals to activate TGFβ in epithelial cells. To understand the role of mesenchymal Gαq/11 in lung de ...[more]