Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer.

ABSTRACT:

Background

Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer immunotherapy. However, the unique features of the immune microenvironment of triple negative breast cancer (TNBC) compared with other subtypes of breast cancer remain elusive. Therefore, we aimed to depict and compare the immune landscape among TNBC, human epidermal growth factor receptor 2-positive (HER2⁺ ) breast cancer, and luminal-like breast cancer.

Methods

Single-cell RNA sequencing (scRNA-seq) was performed on CD45⁺ immune cells isolated from human normal breast tissues and primary breast tumors of various subtypes. By analyzing the scRNA-seq data, immune cell clusters were identified and their prop

SUBMITTER: Ding S 

PROVIDER: S-EPMC10259667 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature