Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors.

ABSTRACT:

Background

Tumors possess incessant growth features, and expansion of their masses demands sufficient oxygen supply by red blood cells (RBCs). In adult mammals, the bone marrow (BM) is the main organ regulating hematopoiesis with dedicated manners. Other than BM, extramedullary hematopoiesis is discovered in various pathophysiological settings. However, whether tumors can contribute to hematopoiesis is completely unknown. Accumulating evidence shows that, in the tumor microenvironment (TME), perivascular localized cells retain progenitor cell properties and can differentiate into other cells. Here, we sought to better understand whether and how perivascular localized pericytes in tumors manipulate hematopoiesis.

Methods

To test if vascular cells can differentiate into RBCs,

SUBMITTER: Hosaka K 

PROVIDER: S-EPMC10259668 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature