Microperimetry as an Outcome Measure in RPGR-associated Retinitis Pigmentosa Clinical Trials.

ABSTRACT:

Purpose

To explore which microperimetry sensitivity index (pointwise sensitivity, mean sensitivity, and volume sensitivity) is suitable as a microperimetry outcome measure in patients with X-linked RPGR-associated retinitis pigmentosa (RP).

Methods

Microperimetry data from patients with RPGR-associated RP were collected and analyzed retrospectively. Fourteen participants completed triplicate microperimetry testing, across 2 consecutive days for the repeatability analyses. Longitudinal data was obtained from 13 participants who completed microperimetry testing at two separate visits.

Results

The test-retest coefficients of repeatability (CoR) for pointwise sensitivity were ±9.5 dB and ±9.3 dB, in the right and left eyes, respectively. The mean sensitivity CoR for the r

SUBMITTER: Taylor LJ 

PROVIDER: S-EPMC10259674 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature