Temporal Dynamics of Metabolic Acquisition in Grafted Engineered Human Liver Tissue.

ABSTRACT: Liver disease affects millions globally, and end-stage liver failure is only cured by organ transplant. Unfortunately, there is a growing shortage of donor organs as well as inequitable access to transplants across populations. Engineered liver tissue grafts that supplement or replace native organ function can address this challenge. While engineered liver tissues have been successfully engrafted previously, the extent to which these tissues express human liver metabolic genes and proteins remains unknown. Here, it is built engineered human liver tissues and characterized their engraftment, expansion, and metabolic phenotype at sequential stages post-implantation by RNA sequencing, histology, and host serology. Expression of metabolic genes is observed at weeks 1-2, followed by the cellula

SUBMITTER: Fortin CL 

PROVIDER: S-EPMC10259871 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature