ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.

ABSTRACT:

Background

Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility disturbances to pain and disfigurement. Due to the high recurrence of the lesions, more effective therapies are needed.

Methods

As targeting stromal cells has been an emerging concept in anti-angiogenic therapies, here, by using VM/AST patient samples, RNA-sequencing, cell culture techniques, and a xenograft mouse model, we investigated the crosstalk of endothelial cells (EC) and fibroblasts and its effect on vascular lesion growth.

Results

We report, for the first time, the expression and secretion of transforming growth factor A (TGFA) i

SUBMITTER: Jauhiainen S 

PROVIDER: S-EPMC10260011 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature