Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue.

ABSTRACT: Mechanosensory ion channels are proteins that are sensitive to mechanical forces. They are found in tissues throughout the body and play an important role in bone remodeling by sensing changes in mechanical stress and transmitting signals to bone-forming cells. Orthodontic tooth movement (OTM) is a prime example of mechanically induced bone remodeling. However, the cell-specific role of the ion channels Piezo1 and Piezo2 in OTM has not been investigated yet. Here we first identify the expression of PIEZO1/2 in the dentoalveolar hard tissues. Results showed that PIEZO1 was expressed in odontoblasts, osteoblasts, and osteocytes, while PIEZO2 was localized in odontoblasts and cementoblasts. We therefore used a Piezo1^{floxed/floxed} mouse model in combination with Dmp1^cre t

SUBMITTER: Nottmeier C 

PROVIDER: S-EPMC10261143 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature