S-EPMC10261263 - [<sup>64</sup>Cu]Cu-DOTATATE PET metrics in the investigation of atherosclerotic inflammation in humans. - OmicsDI

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Dataset Information

[⁶⁴Cu]Cu-DOTATATE PET metrics in the investigation of atherosclerotic inflammation in humans.

ABSTRACT:

Purpose

The aim of this study was to assess and compare the arterial uptake of the inflammatory macrophage targeting PET tracer [⁶⁴Cu]Cu-DOTATATE in patients with no or known cardiovascular disease (CVD) to investigate potential differences in uptake.

Methods

Seventy-nine patients who had undergone [⁶⁴Cu]Cu-DOTATATE PET/CT imaging for neuroendocrine neoplasm disease were retrospectively allocated to three groups: controls with no known CVD risk factors (n = 22), patients with CVD risk factors (n = 24), or patients with known ischemic CVD (n = 33). Both maximum, mean of max and most-diseased segment (mds) standardized uptake value (SUV) and target-to-background ratio (TBR) uptake metrics were measured and reported for the carotid arteries and the aorta. To assess reproducibility between different reviewers, Bland-Altman plots were made.

Results

For the carotid arteries, SUV_max (P = .03), SUV_mds (0.05), TBR_max (P < .01), TBR_mds (P < .01), and mean-of-max TBR (P = .01) were overall shown to provide a group-wise difference in uptake. When measuring uptake values in the aorta, a group-wise difference was only observed with TBR_mds (P = .04). Overall, reproducibility of the reported uptake metrics was excellent for SUVs and good to excellent for TBRs for both the carotid arteries and the aorta.

Conclusion

Using [⁶⁴Cu]Cu-DOTATATE PET imaging as a marker of atherosclerotic inflammation, we were able to demonstrate differences in some of the most frequently reported uptake metrics in patients with different degrees of CVD. Measurements of the carotid artery as either maximum uptake values or most-diseased segment analysis showed the best ability to discriminate between the groups.

SUBMITTER: Jensen JK

PROVIDER: S-EPMC10261263 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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[<sup>64</sup>Cu]Cu-DOTATATE PET metrics in the investigation of atherosclerotic inflammation in humans.

Jensen Jacob K JK Madsen Johanne S JS Jensen Malte E K MEK Kjaer Andreas A Ripa Rasmus S RS

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20220831 3

<h4>Purpose</h4>The aim of this study was to assess and compare the arterial uptake of the inflammatory macrophage targeting PET tracer [<sup>64</sup>Cu]Cu-DOTATATE in patients with no or known cardiovascular disease (CVD) to investigate potential differences in uptake.<h4>Methods</h4>Seventy-nine patients who had undergone [<sup>64</sup>Cu]Cu-DOTATATE PET/CT imaging for neuroendocrine neoplasm disease were retrospectively allocated to three groups: controls with no known CVD risk factors (n = 2 ...[more]

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