Dataset Information

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001-2006.

ABSTRACT:

Objective

To examine the interaction between waist circumference (WC) and serum 25-hydroxyvitamin D (25(OH)D) level in their associations with serum lipids.

Design

Cross-sectional study. The associations of serum 25(OH)D with total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), LDL-C:HDL-C and TAG were examined using multiple linear regression. Effect modification by WC was assessed through cross-product interaction terms between 25(OH)D and WC categories (abdominal overweight, 80-<88 cm in females/94-<102 cm in males; abdominal obesity, ≥88 cm in females/≥102 cm in males).

Setting

The US National Health and Nutrition Examination Survey waves 2001-2006.

Subjects

Non-pregnant fasting participants (n 4342) aged ≥20 years.

Results

Lower 25(OH)D levels were significantly associated with lower HDL-C levels as well as with higher LDL-C:HDL-C and TAG levels in abdominally obese participants, but not in abdominally overweight or normal-waist participants. In contrast, lower 25(OH)D levels were associated with lower levels of total cholesterol and LDL-C in abdominally overweight and normal-waist participants only, but this association was only partly significant. However, a significant difference in the association between 25(OH)D and the lipids according to WC category was found only for LDL-C:HDL-C (P for interaction=0·02).

Conclusions

Our results from this large, cross-sectional sample suggest that the association between lower 25(OH)D levels and an unfavourable lipid profile is stronger in individuals with abdominal obesity than in those with abdominal overweight or a normal WC.

SUBMITTER: Vogt S

PROVIDER: S-EPMC10261314 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001-2006.

Vogt Susanne S Baumert Jens J Peters Annette A Thorand Barbara B Scragg Robert R

Public health nutrition 20160729 10

<h4>Objective</h4>To examine the interaction between waist circumference (WC) and serum 25-hydroxyvitamin D (25(OH)D) level in their associations with serum lipids.<h4>Design</h4>Cross-sectional study. The associations of serum 25(OH)D with total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), LDL-C:HDL-C and TAG were examined using multiple linear regression. Effect modification by WC was assessed through cross-product interaction terms between 25(OH)D and WC categories (abdomina ...[more]

PMID: 27469173

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Project description:BackgroundThere is limited research on the associations between serum nutritional biomarkers and mortality risk in patients with metabolic syndrome (MetS). Existing studies merely investigated the single-biomarker effect. Thus, this study aimed to investigate the combined effect of nutritional biomarker mixtures and mortality risk using the Bayesian kernel machine regression (BKMR) model in patients with MetS.MethodsWe included the MetS patients, defined according to the 2018 Guideline on the Management of Blood Cholesterol from the National Health and Nutrition Examination Survey (NHANES) 2001-2006. A total of 20 serum nutritional biomarkers were measured and evaluated in this study. The Cox proportional hazard model and restricted cubic spline models were used to evaluate the individual linear and non-linear association of 20 nutritional biomarkers with mortality risk. Bayesian kernel machine regression (BKMR) was used to assess the associations between mixture of nutritional biomarkers and mortality risk.ResultsA total of 1455 MetS patients had a median age of 50 years (range: 20-85). During a median of 17.1-year follow-up, 453 (24.72%) died: 146 (7.20%) caused by CVD and 87 (5.26%) by cancer. Non-linear and linear analyses indicated that, in total, eight individual biomarkers (α-carotene, β-carotene, bicarbonate, lutein/zeaxanthin, lycopene, potassium, protein, and vitamin A) were significantly associated with all-cause mortality (all p-values < 0.05). Results from BKMR showed an association between the low levels of the mixture of nutritional biomarkers and high risk of all-cause mortality with the estimated effects ranging from 0.04 to 0.14 (referent: medians). α-Carotene (PIP = 0.971) and potassium (PIP = 0.796) were the primary contributors to the combined effect of the biomarker mixture. The nutritional mixture levels were found to be negatively associated with the risk of cardiovascular disease (CVD) mortality and positively associated with the risk of cancer mortality. After it was stratified by nutrients, the mixture of vitamins showed a negative association with all-cause and CVD mortality, whereas the mixture of mineral-related biomarkers was positively associated with all-cause and cancer mortality.ConclusionOur findings support the evidence that nutritional status was associated with long-term health outcomes in MetS patients. It is necessary for MetS patients to be concerned with certain nutritional status (i.e., vitamins and mineral elements).

Project description:BackgroundWeight-adjusted waist circumference index (WWI) is a novel index related to obesity and has been associated with the risk and prognosis of several diseases. The aim of the study was to determine the association between WWI and myocardial infarction.MethodsThe study analyzed cross-sectional data from 31,535 participants derived from the 1999-2014 National Health and Nutrition Examination Survey (NHANES) dataset. Multiple logistic regression and restricted cubic spline (RCS) analyses were conducted to assess both linear and nonlinear associations between WWI and myocardial infarction. Subgroup analyses and interaction tests were also performed.ResultsAmong the 31,535 participants analyzed, 1,449 (4.82%) had experienced a myocardial infarction. The fully adjusted models demonstrated a positive association between WWI and myocardial infarction [odds ratio (OR) = 1.34, 95% confidence interval (CI): 1.13-1.58]. Individuals in the highest quartile of WWI were 81% more likely to suffer from a myocardial infarction compared to those in the lowest quartile (OR = 1.81, 95% CI: 1.24-2.63). The analysis employing restricted cubic spline modeling indicated a nonlinear positive correlation between WWI and myocardial infarction. The risk of myocardial infarction was 1.29 times higher when WWI was below 10.97 cm/√kg (OR = 2.29, 95% CI: 1.37-3.84). When WWI exceeded 10.97 cm/√kg, the upward trend in the risk of myocardial infarction significantly slowed with increasing WWI (OR = 1.26, 95%CI:1.03-1.56). A threshold WWI value of greater than 11.15 cm/√kg was identified for predicting myocardial infarction, outperforming waist circumference and body mass index (BMI). Subgroup analyses revealed that the impact of WWI on myocardial infarction varied across different populations. Interaction analyses demonstrated significant interactions between myocardial infarction incidence and WWI with age, hypertension, coronary heart disease, angina pectoris, and stroke (P for interaction <0.05), but not with gender, race, obesity, diabetes, or prediabetes and heart failure (P for interaction >0.05).ConclusionsThe findings suggest that there is a positive and non-linear association between WWI and the incidence of myocardial infarction. We recommend incorporating WWI into routine physical examinations and cardiovascular risk screening as an early warning mechanism. This may facilitate early identification of high-risk individuals and promote earlier preventive interventions.

Dataset Information

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001-2006.

Objective

Design

Setting

Subjects

Results

Conclusions

Publications

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001-2006.

Similar Datasets

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