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ABSTRACT: Objective
To test the association between coffee consumption and risk of all-cause, CVD and cancer death in a European cohort.Design
Prospective cohort study. Cox proportional hazards models with adjustment for potential confounders to estimate multivariable hazard ratios (HR) and 95 % CI were used.Setting
Czech Republic, Russia and Poland.Subjects
A total of 28561 individuals followed for 6·1 years.Results
A total of 2121 deaths (43·1 % CVD and 35·7 % cancer mortality) occurred during the follow-up. Consumption of 3-4 cups coffee/d was associated with lower mortality risk in men (HR=0·83; 95 % CI 0·71, 0·99) and women (HR=0·63; 95 % CI 0·47, 0·84), while further intake showed non-significant reduced risk estimates (HR=0·71; 95 % CI 0·49, 1·04 and HR=0·51; 95 % CI 0·24, 1·10 in men and women, respectively). Decreased risk of CVD mortality was also found in men (HR=0·71; 95 % CI 0·54, 0·93) for consumption of 3-4 cups coffee/d. Stratified analysis revealed that consumption of a similar amount of coffee was associated with decreased risk of all-cause (HR=0·61; 95 % CI 0·43, 0·87) and cancer mortality (HR=0·59; 95 % CI 0·35, 0·99) in non-smoking women and decreased risk of all-cause mortality for >4 cups coffee/d in men with no/moderate alcohol intake.Conclusions
Coffee consumption was associated with decreased risk of mortality. The protective effect was even stronger when stratification by smoking status and alcohol intake was performed.
SUBMITTER: Grosso G
PROVIDER: S-EPMC10261370 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Grosso Giuseppe G Stepaniak Urszula U Micek Agnieszka A Stefler Denes D Bobak Martin M Pajak Andrzej A
Public health nutrition 20160714 1
<h4>Objective</h4>To test the association between coffee consumption and risk of all-cause, CVD and cancer death in a European cohort.<h4>Design</h4>Prospective cohort study. Cox proportional hazards models with adjustment for potential confounders to estimate multivariable hazard ratios (HR) and 95 % CI were used.<h4>Setting</h4>Czech Republic, Russia and Poland.<h4>Subjects</h4>A total of 28561 individuals followed for 6·1 years.<h4>Results</h4>A total of 2121 deaths (43·1 % CVD and 35·7 % can ...[more]