Effects of the dipeptides comprising leucine and lysine on lifespan and age-related stress in Caenorhabditis elegans.

ABSTRACT: The aging process is affected by various stressors. An increase in oxidative stress is related to the impairment of physiological functions and enhancement of glycative stress. Food-derived bioactive peptides have various physiological functions, including antioxidant activities. Dipeptides comprising Leu and Lys (LK and KL, respectively) have been isolated from foods; however, their physiological properties remain unclear. In this study, we investigated the antioxidant/antiglycation activity of dipeptides and their antiaging effects using Caenorhabditis elegans (C. elegans). Both dipeptides showed antioxidant activities against several reactive oxygen species (ROS) in vitro. In particular, the scavenging activity of LK against superoxide radicals was higher than KL di

SUBMITTER: Yokoyama I 

PROVIDER: S-EPMC10261761 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature