High-Throughput SARS-CoV-2 Antiviral Testing Method Using the Celigo Image Cytometer.

ABSTRACT: The COVID-19 pandemic has created a worldwide public health crisis that has since resulted in 6.8 million reported deaths. The pandemic prompted the immediate response of researchers around the world to engage in rapid vaccine development, surveillance programs, and antiviral testing, which resulted in the delivery of multiple vaccines and repurposed antiviral drug candidates. However, the emergence of new highly transmissible SARS-CoV-2 variants has renewed the desire for discovering new antiviral drug candidates with high efficacy against the emerging variants of concern. Traditional antiviral testing methods employ the plaque-reduction neutralization tests (PRNTs), plaque assays, or RT-PCR analysis, but each assay can be tedious and time-consuming, requiring 2-3 days to complete the ini

SUBMITTER: St Clair LA 

PROVIDER: S-EPMC10261830 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature