The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice.

ABSTRACT:

Background

Radiotherapy for non-small cell lung cancer (NSCLC) can be dose-limiting due to treatment-related toxicities. Genistein has been shown to be a robust radioprotective agent in preclinical models. A novel genistein oral nanosuspension formulation (nano-genistein) has demonstrated efficacy in mitigating radiation-induced lung damage in preclinical animal models. However, while those studies have confirmed that nano-genistein can protect normal lung tissue from radiation-induced toxicities, no studies have assessed the effect of nano-genistein on lung tumors. Here, we evaluated the impact of nano-genistein on the efficacy of radiation treatment of lung tumors in a mouse xenograft model.

Methods

Two separate studies were conducted utilizing human A549 cells implanted e

SUBMITTER: Kaytor MD 

PROVIDER: S-EPMC10261856 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature