Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer.

ABSTRACT:

Background

Tumor local and distant relapse recurrence after radiotherapy (RT) is one of the critical factors leading to poor prognosis. The effective antitumor effects of RT are dependent upon the participation of innate and adaptive components of the immune system. C5a/C5aR1 signaling can regulate antitumor immune effect in the tumor microenvironment (TME). Thus, exploring the changes and mechanism in the TME induced by RT-mediated complement activation may provide a novel perspective for reversing radioresistance.

Methods

First, fractionated radiation of 8 Gy ×3 fractions were targeted at Lewis lung carcinoma (LLC) tumor-bearing female mice to measure the infiltration of CD8⁺ T cell and analyze the RNA sequencing (RNA-seq) in RT-recruited CD8⁺ T cells

SUBMITTER: Yuan M 

PROVIDER: S-EPMC10261863 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature