Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.

ABSTRACT: The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250.

SUBMITTER: Fox BA 

PROVIDER: S-EPMC10261915 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature