Association of Adverse Childhood Experiences With Accelerated Epigenetic Aging in Midlife.

ABSTRACT:

Importance

Adverse childhood experiences (ACEs) are associated with the risk of poorer health, and identifying molecular mechanisms may lay the foundation for health promotion in people with ACEs.

Objective

To investigate the associations of ACEs with changes in epigenetic age acceleration (EAA), a biomarker associated with various health outcomes in middle-aged adults, in a population with balanced race and sex demographics.

Design, setting, and participants

Data for this cohort study were from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants in CARDIA underwent 8 follow-up exams from baseline (year 0 [Y0]; 1985-1986) to Y30 (2015-2016), and participant blood DNA methylation information was obtained at Y15 (2000-2001) and Y20 (2005-20

SUBMITTER: Kim K 

PROVIDER: S-EPMC10261996 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature