Guidance on the management of adverse reactions induced by poly(ADP-ribose) polymerase inhibitors.

ABSTRACT: The common adverse reactions caused by poly (ADP-ribose) polymerase (PARP) inhibitors include hematological toxicity, gastrointestinal toxicity and fatigue. The main prevention and treatment of hematological toxicity include: regular blood tests, referral to hematology department when routine treatment is ineffective, and being alert of myelodysplastic syndrome/acute myeloid leukemia. The key points to deal with gastrointestinal toxicity include: taking medicine at the right time, light diet, appropriate amount of drinking water, timely symptomatic treatment, prevention of expected nausea and vomiting, and so on. For fatigue, full assessment should be completed before treatment because the causes of fatigue are various; the management includes massage therapy, psychosocial interventions an

SUBMITTER: Society of Obstetrics and Gynecology of Zhejiang Medical Association 

PROVIDER: S-EPMC10262009 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature