Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion.

ABSTRACT:

Aims

Recent studies have suggested a key role of intestinal microbiota in pathological progress of multiple organs via immune modulation. However, the interactions between heart and gut microbiota remain to be fully elucidated. The aim of the study is to investigate the role of gut microbiota in the post-ischaemia/reperfusion (I/R) inflammatory microenvironment.

Methods and results

Here, we conducted a case-control study to explore the association of gut bacteria translocation products with inflammation biomarkers and I/R injury severity in ST-elevation myocardial infarction patients. Then, we used a mouse model to determine the effects of myocardial I/R injury on gut microbiota dysbiosis and translocation. Blooming of Proteobacteria was identified as a hallmark of post-I/R

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10262181 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature