Disrupting circadian control of peripheral myogenic reactivity mitigates cardiac injury following myocardial infarction.

ABSTRACT:

Aims

Circadian rhythms orchestrate important functions in the cardiovascular system: the contribution of microvascular rhythms to cardiovascular disease progression/severity is unknown. This study hypothesized that (i) myogenic reactivity in skeletal muscle resistance arteries is rhythmic and (ii) disrupting this rhythmicity would alter cardiac injury post-myocardial infarction (MI).

Methods and results

Cremaster skeletal muscle resistance arteries were isolated and assessed using standard pressure myography. Circadian rhythmicity was globally disrupted with the ClockΔ19/Δ19 mutation or discretely through smooth muscle cell-specific Bmal1 deletion (Sm-Bmal1 KO). Cardiac structure and function were determined by echocardiographic, hemodynamic and histological assessments. Myo

SUBMITTER: Kroetsch JT 

PROVIDER: S-EPMC10262184 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature