Quantification of cell behaviors and computational modeling show that cell directional behaviors drive zebrafish pectoral fin morphogenesis.

ABSTRACT:

Motivation

Understanding the mechanisms by which the zebrafish pectoral fin develops is expected to produce insights on how vertebrate limbs grow from a 2D cell layer to a 3D structure. Two mechanisms have been proposed to drive limb morphogenesis in tetrapods: a growth-based morphogenesis with a higher proliferation rate at the distal tip of the limb bud than at the proximal side, and directed cell behaviors that include elongation, division and migration in a non-random manner. Based on quantitative experimental biological data at the level of individual cells in the whole developing organ, we test the conditions for the dynamics of pectoral fin early morphogenesis.

Results

We found that during the development of the zebrafish pectoral fin, cells have a preferential elonga

SUBMITTER: Dokmegang J 

PROVIDER: S-EPMC10262313 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature