Combination of CEACAM5, EpCAM and CK19 gene expressions in mediastinal lymph node micrometastasis is a prognostic factor for non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer is known as the most common and highly metastatic form of cancer worldwide. Tumour node metastasis (TNM) staging is the gold standard classification system for the decision-making process for appropriate treatment. Particularly N status has the most important prognostic value in the absence of distant metastasis. Traditional diagnostic methods are capable of detecting metastasis; however, they may fail to detect micrometastasis, which plays a role in disease recurrence and patients' long-term survival. Occult micrometastasis can change the tumour's TNM staging and, consequently, the patient's treatment regimen.

Methods

The median number of three lymph node tissues were collected from 30 patients who underwent surgery for non-small cell lung cancer. Lym

SUBMITTER: Suer H 

PROVIDER: S-EPMC10262366 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature