Transcriptional profile of Trichomonas vaginalis in response to metronidazole.

ABSTRACT:

Background

Trichomoniasis caused by Trichomonas vaginalis, combined with its complications, has long frequently damaged millions of human health. Metronidazole (MTZ) is the first choice for therapy. Therefore, a better understanding of its trichomonacidal process to ultimately reveal the global mechanism of action is indispensable. To take a step toward this goal, electron microscopy and RNA sequencing were performed to fully reveal the early changes in T. vaginalis at the cellular and transcriptome levels after treatment with MTZ in vitro.

Results

The results showed that the morphology and subcellular structures of T. vaginalis underwent prominent alterations, characterized by a rough surface with bubbly protrusions, broken holes and deformed nuclei with decreased nuclear m

SUBMITTER: Xie Y 

PROVIDER: S-EPMC10262402 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature