Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system.

ABSTRACT:

Background

Various renal abnormalities, including hydronephrosis, polycystic kidney disease, and hydroureter, have been reported, and these abnormalities are present in DiGeorge syndrome, renal dysplasia, and acute kidney failure. Previous studies have shown that various genes are associated with renal abnormalities. However, the major target genes of nonobstructive hydronephrosis have not yet been elucidated.

Results

We examined neuroblast differentiation-associated protein Ahnak localization and analyzed morphogenesis in developing kidney and ureter. To investigated function of Ahnak, RNA-sequencing and calcium imaging were performed in wild type and Ahnak knockout (KO) mice. Ahnak localization was confirmed in the developing mouse kidneys and ureter. An imbalance of calci

SUBMITTER: Lee JM 

PROVIDER: S-EPMC10262403 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature