Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases.

ABSTRACT:

Background

We aimed to evaluate the impacts of metabolomic body mass index (metBMI) phenotypes on the risks of cardiovascular and ocular diseases outcomes.

Methods

This study included cohorts in UK and Guangzhou, China. By leveraging the serum metabolome and BMI data from UK Biobank, this study developed and validated a metBMI prediction model using a ridge regression model among 89,830 participants based on 249 metabolites. Five obesity phenotypes were obtained by metBMI and actual BMI (actBMI): normal weight (NW, metBMI of 18.5-24.9 kg/m²), overweight (OW, metBMI of 25-29.9 kg/m²), obesity (OB, metBMI ≥ 30 kg/m²), overestimated (OE, metBMI-actBMI > 5 kg/m²), and underestimated (UE, metBMI-actBMI < - 5 kg/m²). Additiona

SUBMITTER: Zhong P 

PROVIDER: S-EPMC10262415 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature