Association between polygenic risk for Alzheimer's disease and brain structure in children and adults.

ABSTRACT:

Background

The correlations between genetic risk for Alzheimer's disease (AD) with comprehensive brain regions at a regional scale are still not well understood. We aim to explore whether these associations vary across different age stages.

Methods

This study used large existing genome-wide association datasets to calculate polygenic risk score (PRS) for AD in two populations from the UK Biobank (N ~ 23 000) and Adolescent Brain Cognitive Development Study (N ~ 4660) who had multimodal macrostructural and microstructural magnetic resonance imaging (MRI) metrics. We used linear mixed-effect models to assess the strength of the association between AD PRS and multiple MRI metrics of regional brain structures at different stages of life.

Results

Compared to those with low

SUBMITTER: He XY 

PROVIDER: S-EPMC10262429 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature