Buffy coat signatures of breast cancer risk in a prospective cohort study.

ABSTRACT:

Background

Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These findings offer promising applications in cancer detection, subtyping, and treatment monitoring. However, much of the current evidence is based on findings in retrospective studies and may reflect epigenetic patterns that have already been influenced by the onset of the disease.

Methods

Studying breast cancer, we established genome-scale DNA methylation profiles of prospectively collected buffy coat samples (n = 702) from a case-control study nested within the EPIC-Heidelberg cohort using reduced representation bisulphite sequencing (RRBS).

Results

We observed cancer-specifi

SUBMITTER: Chung FF 

PROVIDER: S-EPMC10262593 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature