Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review.

ABSTRACT: Reported here is a case of rapidly progressive metastatic castration-resistant prostate cancer treated with [¹⁷⁷Lu]Lu-PSMA-617 in the setting of severe renal impairment and impending ureteric obstruction. PSMA is expressed on renal tubular cells, raising the possibility of radiation-induced nephrotoxicity, and this level of renal impairment would typically exclude the patient from [¹⁷⁷Lu]Lu-PSMA-617 therapy. Multidisciplinary input, individualized dosimetry, and patient-specific dose reduction were used to ensure the cumulative dose to the kidneys remained within acceptable limits. He was initially planned for treatment with six cycles of [¹⁷⁷Lu]Lu-PSMA-617. However, he had an excellent response to therapy following four cycles of treatment and the last two

SUBMITTER: Sutherland DEK 

PROVIDER: S-EPMC10262655 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature