Association of modifiable lifestyle with colorectal cancer incidence and mortality according to metabolic status: prospective cohort study.

ABSTRACT:

Background

Metabolic syndrome has been linked to an increased risk of colorectal cancer (CRC) incidence and mortality, but whether adopting a healthy lifestyle could attenuate the risk of CRC conferred by metabolic syndrome remains unclear. The aim of the study is to investigate the individual and joint effects of modifiable healthy lifestyle and metabolic health status on CRC incidence and mortality in the UK population.

Methods

This prospective study included 328,236 individuals from the UK Biobank. An overall metabolic health status was assessed at baseline and categorized based on the presence or absence of metabolic syndrome. We estimated the association of the healthy lifestyle score (derived from 4 modifiable behaviors: smoking, alcohol consumption, diet, physical act

SUBMITTER: Xie P 

PROVIDER: S-EPMC10262687 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature