GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.

ABSTRACT: There is growing recognition that regionalization of bacterial colonization and immunity along the intestinal tract has an important role in health and disease. Yet, the mechanisms underlying intestinal regionalization and its dysregulation in disease are not well understood. This study found that regional epithelial expression of the transcription factor GATA4 controls bacterial colonization and inflammatory tissue immunity in the proximal small intestine by regulating retinol metabolism and luminal IgA. Furthermore, in mice without jejunal GATA4 expression, the commensal segmented filamentous bacteria promoted pathogenic inflammatory immune responses that disrupted barrier function and increased mortality upon Citrobacter rodentium infection. In celiac disease patients, low GATA4 express

SUBMITTER: Earley ZM 

PROVIDER: S-EPMC10262782 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature