Temporal and coevolutionary analyses reveal the events driving the emergence and circulation of human mamastroviruses.

ABSTRACT: Characterized by high genetic diversity, broad host range, and resistance to adverse conditions, coupled with recent reports of neurotropic astroviruses circulating in humans, mamastroviruses pose a threat to public health. The current astrovirus classification system based on host source prevents determining whether strains with distinct tropism or virulence are emerging. By using integrated phylogeny, we propose a standardized demarcation of species and genotypes, with reproducible cut-off values that reconcile the pairwise sequence distribution, genetic distances between lineages, and the topological reconstruction of the Mamastrovirus genus. We further define the various links established by co-evolution and resolve the dynamics of transmission chains to identify host-jump event

SUBMITTER: Perez LJ 

PROVIDER: S-EPMC10262812 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature