Hypothyroidism and rheumatoid arthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Meta-analysis of genome-wide association studies (GWAS) data showed that the relationship between hypothyroidism and rheumatoid arthritis (RA) risk remains under debate. This study is conducted to test the causal relationship of hypothyroidism and RA.

Methods

A two-sample Mendelian randomization (TSMR) analysis was employed to estimate the causality of hypothyroidism and rheumatoid arthritis in European ancestry and Asian ancestry. Integrating the effects generated by TSMR, functional annotations and noncoding variant prediction framework were applied to analyze and interpret the functional instrument variants (IVs).

Results

The results of the inverse variance weighted method showed a strong significant causal relationship between hypothyroidism and risk of

SUBMITTER: Gao Y 

PROVIDER: S-EPMC10262846 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature