Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8⁺ T cells.

ABSTRACT: The autoimmune pathogenesis of type 1 diabetes (T1D) involves cellular infiltration from innate and adaptive immune subsets into the islets of Langerhans within the pancreas; however, the direct cytotoxic killing of insulin-producing β-cells is thought to be mediated primarily by antigen-specific CD8⁺ T cells. Despite this direct pathogenic role, key aspects of their receptor specificity and function remain uncharacterized, in part, due to their low precursor frequency in peripheral blood. The concept of engineering human T cell specificity, using T cell receptor (TCR) and chimeric antigen receptor (CAR)-based approaches, has been demonstrated to improve adoptive cell therapies for cancer, but has yet to be extensively employed for modeling and treating autoimmunity. To address

SUBMITTER: Peters LD 

PROVIDER: S-EPMC10262917 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature