Ontology highlight
ABSTRACT:
SUBMITTER: Godesi S
PROVIDER: S-EPMC10263210 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Pharmaceuticals (Basel, Switzerland) 20230502 5
MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested compounds, compound <b>50</b> containing a piperidine ring displayed an improved growth inhibition of A549 and H460 lung cancer cell lines compared with <b>LW1497</b>. Compound <b>50</b> reduced the total ATP content in A549 cells in a dose-dependent ...[more]