Liver-Resident Bystander CD8⁺ T Cells Contribute to Liver Disease Pathogenesis in Chronic Hepatitis D Virus Infection.

ABSTRACT:

Background & aims

The hepatitis D virus (HDV) causes the most severe form of chronic hepatitis, often progressing to cirrhosis within 5 to 10 years. There is no curative treatment, and the mechanisms underlying the accelerated liver disease progression are unknown.

Methods

Innate and adaptive immune responses were studied in blood and liver of 24 patients infected with HDV and 30 uninfected controls by multiparameter flow cytometry in correlation with disease severity and stage.

Results

The 2 main intrahepatic innate immune-cell populations, mucosal-associated invariant T cells and natural killer (NK) cells, were reduced in the livers of patients infected with HDV compared with those of uninfected controls but were more frequently activated in the liver compared with

SUBMITTER: Kefalakes H 

PROVIDER: S-EPMC10263257 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature