Low responsiveness of peripheral lymphocytes in extraparenchymal neurocysticercosis.

ABSTRACT:

Background

The morbidity and mortality of extraparenchymal neurocysticercosis (EP-NC) remain high and effectiveness of current medical treatment is suboptimal. Various factors have been implicated in the severity of EP-NC and in the poor response to treatment, but the possible role of host immune and endocrine systems has not yet been examined thoroughly.

Methodology/principal findings

42 participants with EP-NC before receiving standard treatment and 25 healthy controls were included in the study. Treatment response was assessed by comparing pre/post treatment parasite volumes from 3D MRI. Prior to treatment among participants with EP-NC, specific stimulation induced an increased specific proliferative response accompanied by a significant increase in IL-4, NK, NKT, Bregs a

SUBMITTER: Romo ML 

PROVIDER: S-EPMC10263342 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature