Investigating association between gut microbiota and sarcopenia-related traits: a Mendelian randomization study

ABSTRACT: Abstract

Background

Observational studies have indicated a potential link between gut microbiota and sarcopenia. However, the underlying mechanisms and a causal relationship have not been established. Thus, the objective of this study is to examine the possible causal association between gut microbiota and sarcopenia-related traits, including low hand-grip strength and appendicular lean mass (ALM), to shed light on the gut–muscle axis.

Methods

To investigate the potential impact of gut microbiota on low hand-grip strength and ALM, we utilized a two-sample Mendelian randomization (MR) approach. Summary statistics were obtained from genome-wide association studies of gut microbiota, low hand-grip strength, and ALM. The primary MR analysis employed the random-effects inverse

SUBMITTER:  

PROVIDER: S-EPMC10263384 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature