Ambient PM_2.5 exposure and salivary cortisol output during pregnancy in a multi-ethnic urban sample.

ABSTRACT:

Objectives

Evidence from murine research supports that fine particulate matter (PM_2.5) may stimulate the hypothalamic-pituitary-adrenal axis, leading to elevated circulating glucocorticoid levels. Epidemiologic research examining parallel associations document similar associations. We examined these associations among a diverse sample of pregnant individuals exposed to lower levels of ambient PM_2.5.

Materials and methods

Participants included pregnant individuals enrolled in the PRogramming of Intergenerational Stress Mechanisms (PRISM) pre-birth cohort. Daily residential PM_2.5 exposure was estimated using a satellite-based spatial-temporal hybrid model. Maternal 3rd trimester salivary cortisol levels were used to calculate several features o

SUBMITTER: Cowell W 

PROVIDER: S-EPMC10264094 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature