Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles.

ABSTRACT:

Background

Adoptive T cell therapy (ATCT) has been successful in treating hematological malignancies and is currently under investigation for solid-tumor therapy. In contrast to existing chimeric antigen receptor (CAR) T cell and/or antigen-specific T cell approaches, which require known targets, and responsive to the need for targeting a broad repertoire of antigens in solid tumors, we describe the first use of immunostimulatory photothermal nanoparticles to generate tumor-specific T cells.

Methods

Specifically, we subject whole tumor cells to Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) before culturing with dendritic cells (DCs), and subsequent stimulation of T cells. This strategy differs from previous approaches using tumor cell lysates because we us

SUBMITTER: Sweeney EE 

PROVIDER: S-EPMC10264146 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature