Alanine-based spacers promote an efficient antigen processing and presentation in neoantigen polypeptide vaccines.

ABSTRACT: Neoantigens are tumor-specific antigens that are mostly particular for each patient. Since the immune system is able to mount a specific immune response against these neoantigens, they are a promising tool for the development of therapeutic personalized cancer vaccines. Neoantigens must be presented to T cells by antigen presenting cells (APC) in the context of MHC-I or MHC-II molecules. Therefore, the strategy of vaccine delivery may have a major impact on the magnitude and quality of T cell responses. Neoantigen-based vaccines are frequently administered as a pool of individual synthetic peptides that induce mainly CD4⁺ T cell responses. MHC-I-mediated presentation and the elicitation of CD8⁺ T cell responses may be improved using DNA or RNA sequences that code for

SUBMITTER: Aguilar-Gurrieri C 

PROVIDER: S-EPMC10264286 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature